The current opioid epidemic has increased at an alarming rate. From 2000 to 2015, from the United States and Canada, to Europe and South America, about half a million people have died from opioid-related drug overdoses. This article identifies and discusses recently proposed or finalized noteworthy US statutes and regulations applicable to the substance-use-disorder industry, promulgated by both federal agencies and state legislatures in response to the nationwide opioid addiction crises.